Our scientific publications in high-quality journals reflect the quality of the innovative research in Entasis’ laboratories.

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Alm RA, Lahiri SD, Kutschke A, Otterson LG, McLaughlin RE, Whiteaker JD, Lewis LA, Su X, Huband MD, Gardner H, and Mueller JP

Characterization of the novel DNA gyrase inhibitor AZD0914: low resistance potential and lack of cross-resistance in Neisseria gonorrhoeae

Antimicrobial Agents and Chemotherapy (2015)

Xiong H, Chen B, Durand-Réville TF, Joubran C, Alelyunas YW, Wu D, and Huynh H

Enantioselective synthesis and profiling of two novel diazabicyclooctanone β-lactamase inhibitors

ACS Medicinal Chemistry Letters (2014)

Campbell AJ, Lamb ML, and Joseph-McCarthy D

Ensemble-based docking using biased molecular dynamics

Journal of Chemical Information and Modeling (2014)

Kohlhoff SA, Huband MD, and Hammerschlag MR

In vitro activity of AZD0914, a novel DNA gyrase inhibitor, against Chlamydia trachomatis and Chlamydia pneumoniae

Antimicrobial Agents and Chemotherapy (2014)

Huband MD, Bradford PA, Otterson LG, Basarab GS, Kutschke AC, Giacobbe RA, Patey SA, Alm RA, Johnstone MR, Potter ME, Miller PF, and Mueller JP

In vitro antibacterial activity of AZD0914: a new spiropyrimidinetrione DNA gyrase/topoisomerase inhibitor with potent activity against Gram-positive, fastidious Gram-negative, and atypical bacteria

Antimicrobial Agents and Chemotherapy (2015)

Brown DG, May-Dracka TL, Gagnon MM, and Tommasi R

Trends and exceptions of physical properties on antibacterial activity for Gram-positive and Gram-negative pathogens

Journal of Medicinal Chemistry (2014)

Basarab GS, Brassil P, Doig P, Galullo V, Haimes HB, Kern G, Kutschke A, McNulty J, Schuck VJ, Stone G, and Gowravaram M

Novel DNA gyrase inhibiting spiropyrimidinetriones with a benzisoxazole scaffold: SAR and in vivo characterization

Journal of Medicinal Chemistry (2014)