Publications

Our scientific publications in high-quality journals reflect the quality of the innovative research in Entasis’ laboratories.

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Lancaster JW, Mahoney MV, Mandal S, and Lawrence KR

Update on treatment options for gonococcal infections

Pharmacotherapy (2015)

Biedenbach DJ, Huband MD, Hackel M, de Jonge BL, Sahm DF, and Bradford PA

In vitro activity of AZD0914, a novel bacterial DNA gyrase/topoisomerase IV inhibitor, against clinically relevant Gram-positive and fastidious Gram-negative pathogens

Antimicrobial Agents and Chemotherapy (2015)

Basarab GS, Kern G, McNulty J, Mueller JP, Lawrence K, Vishwanathan K, Alm RA, Barvian K, Doig P, Galullo V, Gardner H, Gowravaram M, Huband M, Kimzey A, Morningstar M, Kutschke A, Lahiri SD, Perros M, Singh R, Schuck V, Tommasi R, Walkup G, and Newman J

Responding to the challenge of untreatable gonorrhea: ETX0914, a first-in-class agent with a distinct mechanism-of-action against bacterial type II topoisomerases

Nature Scientific Reports (2015)

Kern G, Palmer T, Ehmann DE, Shapiro AB, Andrews B, Basarab GS, Doig P, Fan J, Gao N, Mills SD, Mueller J, Sriram S, Thresher J, and Walkup G

Inhibition of Neisseria gonorrhoeae type II topoisomerases by the novel spiropyrimidinetrione AZD0914

Journal of Biological Chemistry (2015)

Basarab GS, Doig P, Galullo V, Kern G, Kimzey A, Kutschke A, Newman J, Morningstar M, Mueller J, Otterson L, Vishwanathan K, Zhou F, and Gowravaram M

Discovery of novel DNA gyrase inhibiting spiropyrimidinetriones – benzisoxazole fusion with N-linked oxazolidinone substituents leading to a clinical candidate (ETX0914)

Journal of Medicinal Chemistry (2015)

Perros M

A sustainable model for antibiotics

Science (2015)

Penwell WF, Shapiro AB, Giacobbe RA, Gu RF, Gao N, Thresher J, McLaughlin RE, Huband MD, DeJonge BLM, Ehmann DE, and Miller AA

The molecular mechanisms of sulbactam antibacterial activity and resistance determinants in Acinetobacter baumannii

Antimicrobial Agents and Chemotherapy (2015)

Waites KB, Crabb DM, Duffy LB, and Huband MD

In vitro Antibacterial activity of AZD0914 against human mycoplasmas and ureaplasmas

Antimicrobial Agents and Chemotherapy (2015)

Tommasi R, Brown DG, Walkup GK, Manchester JI, and Miller AA

ESKAPing the labyrinth of antibacterial discovery

Nature Reviews Drug Discovery (2015)

Zhou Y, Joubran C, Miller-Vedam L, Isabella V, Nayar A, Tentarelli S, and Miller A

Thinking outside the “bug”: a unique assay to measure intracellular drug penetration in Gram-negative bacteria

Analytical Chemistry (2015)