Publications

Shapiro AB, Gao N, Gu R, Thresher J

Fluorescence anisotropy-based measurement of acylation rate constants for inhibitors of Penicillin-Binding Protein 2 (PBP2) transpeptidase of Pseudomonas aeruginosa

Analytical Biochemistry (2014)

Jacobsson S, Golparian D, Alm RA, Huband M, Mueller J, Skov Jensen J, Ohnishi M, Unemoa M

High in vitro activity of the novel spiropyrimidinetrione AZD0914, a DNA gyrase inhibitor, against multidrug resistant Neisseria gonorrhoeae isolates suggests a new effective option for oral treatment of gonorrhea

Antimicrobial Agents and Chemotherapy (2014)

Kohlhoff S, Huband M, Hammerschlag M

In vitro activity of AZD0914, a novel DNA gyrase inhibitor, against Chlamydia trachomatis and Chlamydia pneumoniae

Antimicrobial Agents and Chemotherapy (2014)

Huband M, Bradford P, Otterson L, Basarab G, Kutschke A, Giacobbe R, Patey S, Alm R, Johnstone M, Potter M, Miller P, Mueller J

In Vitro Antibacterial Activity of AZD0914: A New Spiropyrimidinetrione DNA Gyrase/Topoisomerase Inhibitor with Potent Activity against Gram-Positive, Fastidious Gram-Negative, and Atypical Bacteria

Antimicrobial Agents and Chemotherapy (2014)

Olivier NB, Altman RB, Noeske J, Basarab G, Code E, Ferguson AD, Gao N, Huang J, Juette M, Livchak S, Miller MD, Prince DB, Cate JHD, Buurman ET, Blanchard

Negamycin induces translational stalling and miscoding by binding to the small subunit head domain of the Escherichia coli ribosome

PNAS (2014)

Brown DG, May-Dracka TL, Gagnon MM, Tommasi R

Trends and Exceptions of Physical Properties on Antibacterial Activity for Gram-Positive and Gram-Negative Pathogens

Journal of Medicinal Chemistry (2014)

Basarab GS, Brassil P, Doig P, Galullo V, Haimes HB, Kern G, Kutschke A, McNulty J, Schuck VJ, Stone G, Gowravaram M

Novel DNA Gyrase Inhibiting Spiropyrimidinetriones with a Benzisoxazole Scaffold: SAR and in Vivo Characterization

Journal of Medicinal Chemistry (2014)

Basarab G, Galullo V, DeGrace N, Hauck S, Joubran C, Wesolowski S

Synthesis of a Tetrahydronaphthyridine Spiropyrimidinetrione DNA Gyrase Inhibiting Antibacterial Agent – Differential Substitution at all Five Carbon Atoms of Pyridine

Organic Letters (2014)

Shapiro AB, Austin CA

A high-throughput fluorescence anisotropy-based assay for human topoisomerase IIb-catalyzed ATP-dependent supercoiled DNA relaxation

Analytical Biochemistry (2014)

Shapiro AB

A high-throughput-compatible, fluorescence anisotropy-based assay for ATP-dependent supercoiled DNA relaxation by human topoisomerase IIα

Biochemical Pharmacology (2013)