Our scientific publications in high-quality journals reflect the quality of the innovative research in Entasis’ laboratories.

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Xiong H, Chen B, Durand-Réville T, Joubran C, Alelyunas Y, Wu D,Huynh H

Enantioselective Synthesis and Profiling of Two Novel Diazabicyclooctanone ß-Lactamase Inhibitors

ACS Publications (2014)

Campbell AJ, Lamb ML, Joseph-McCarthy D

Ensemble-Based Docking Using Biased Molecular Dynamics

Journal of Chemical Information and Modeling (2014)

Kohlhoff S, Huband M, Hammerschlag M

In vitro activity of AZD0914, a novel DNA gyrase inhibitor, against Chlamydia trachomatis and Chlamydia pneumoniae

Antimicrobial Agents and Chemotherapy (2014)

Huband M, Bradford P, Otterson L, Basarab G, Kutschke A, Giacobbe R, Patey S, Alm R, Johnstone M, Potter M, Miller P, Mueller J

In Vitro Antibacterial Activity of AZD0914: A New Spiropyrimidinetrione DNA Gyrase/Topoisomerase Inhibitor with Potent Activity against Gram-Positive, Fastidious Gram-Negative, and Atypical Bacteria

Antimicrobial Agents and Chemotherapy (2014)

Olivier NB, Altman RB, Noeske J, Basarab G, Code E, Ferguson AD, Gao N, Huang J, Juette M, Livchak S, Miller MD, Prince DB, Cate JHD, Buurman ET, Blanchard

Negamycin induces translational stalling and miscoding by binding to the small subunit head domain of the Escherichia coli ribosome

PNAS (2014)

Brown DG, May-Dracka TL, Gagnon MM, Tommasi R

Trends and Exceptions of Physical Properties on Antibacterial Activity for Gram-Positive and Gram-Negative Pathogens

Journal of Medicinal Chemistry (2014)

Basarab GS, Brassil P, Doig P, Galullo V, Haimes HB, Kern G, Kutschke A, McNulty J, Schuck VJ, Stone G, Gowravaram M

Novel DNA Gyrase Inhibiting Spiropyrimidinetriones with a Benzisoxazole Scaffold: SAR and in Vivo Characterization

Journal of Medicinal Chemistry (2014)