Publications

Our scientific publications in high-quality journals reflect the quality of the innovative research in Entasis’ laboratories.

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Shapiro AB, Gao N, Jahić H, Carter NM, Chen A, and Miller AA

Reversibility of covalent, broad-spectrum serine β-lactamase inhibition by the diazabicyclooctenone ETX2514

ACS Infectious Diseases (2017)

Iyer R, Sylvester MA, Velez-Vega C, Tommasi R, Durand-Réville TF, and Miller AA

Whole-cell-based assay to evaluate structure permeation relationships for carbapenem passage through the Pseudomonas aeruginosa porin OprD

ACS Infectious Diseases (2017)

Papp JR, Lawrence K, Sharpe S, Mueller J, and Kirkcaldy RD

In vitro growth of multidrug-resistant Neisseria gonorrhoeae isolates is inhibited by ETX0914, a novel spiropyrimidinetrione

International Journal of Antimicrobial Agents (2016)

Giacobbe RA, Huband MD, deJonge BLM, and Bradford PA

Effect of susceptibility testing conditions on the in vitro antibacterial activity of ETX0914

Diagnostic Microbiology and Infectious Disease (2017)

Guo J, Joubran C, Luzietti RA Jr, Basarab GS, Grimm SW, and Vishwanathan K

Absorption, distribution, metabolism and elimination of 14C-ETX0914, a novel inhibitor of bacterial type-II topoisomerases in rodents

Xenobiotica (2016)

Foerster S, Golparian D, Jacobsson S, Hathaway LJ, Low N, Shafer WM, Althaus CL, and Unemo M

Genetic resistance determinants, in vitro time-kill curve analysis and pharmacodynamic functions for the novel topoisomerase II inhibitor ETX0914 (AZD0914) in Neisseria gonorrhoeae

Frontiers in Microbiology (2015)

Su XH, Wang BX, Le WJ, Liu YR, Wan C, Li S, Alm RA, Mueller JP, and Rice PA

Multidrug resistant Neisseria gonorrhoeae from Nanjing are sensitive to killing by a novel DNA gyrase inhibitor, ETX0914 (AZD0914)

Antimicrobial Agents and Chemotherapy (2015)