Publications

Our scientific publications in high-quality journals reflect the quality of the innovative research in Entasis’ laboratories.

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Guo J, Joubran C, Luzietti RA Jr, Basarab GS, Grimm SW, Vishwanathan K

Absorption, distribution, metabolism and elimination of 14C-ETX0914, a novel inhibitor of bacterial type-II topoisomerases in rodents

Xenobiotica (2016)

Foerster S, Golparian D, Jacobsson S, Hathaway L, Low N, Shafer W, Althaus C, Unemo M

Genetic resistance determinants, in vitro time-kill curve analysis and pharmacodynamic functions for the novel topoisomerase II inhibitor ETX0914 (AZD0914) in Neisseria gonorrhoeae

Frontiers in Microbiology (2015)

Su XH, Wang BX, Le WJ, Liu YR, Wan C, Li S, Alm RA, Mueller JP, Rice PA

Multidrug resistant Neisseria gonorrhoeae from Nanjing are sensitive to killing by a novel DNA gyrase inhibitor, ETX0914 (AZD0914)

Antimicrobial Agents Chemotherapy (2015)

Lancaster JW, Mahoney MV, Mandal S, Lawrence KR

Update on Treatment Options for Gonococcal Infections

Pharmacotherapy (2015)

Biedenbach DJ, Huband MD, Hackel M, de Jonge BL, Sahm DF, Bradford PA

In vitro Activity of AZD0914, a Novel Bacterial DNA Gyrase/Topoisomerase IV Inhibitor, Against Clinically Relevant Gram-positive and Fastidious Gram-negative Pathogens

Antimicrobial Agents and Chemotherapy (2015)

Basarab GS, Kern G, McNulty J, Mueller JP, Lawrence K, Vishwanathan K, Alm RA, Barvian K, Doig P, Galullo V, Gardner H, Gowravaram M, Huband M, Kimzey A, Morningstar M, Kutschke A, Lahiri SD, Perros M, Singh R, Schuck V, Tommasi R, Walkup G, Newman J

Responding to the challenge of untreatable gonorrhea: ETX0914, a first-in-class agent with a distinct mechanism-of-action against bacterial Type II topoisomerases

Nature Scientific Reports (2015)

Kern G , Palmer T, Ehmann DE, Shapiro AB, Andrews B, Basarab GS, Doig P, Fan J, Gao N, Mills SD, Mueller J, Sriram S, Thresher J, Walkup G

Inhibition of Neisseria gonorrhoeae type II Topoisomerases by the Novel Spiropyrimidinetrione AZD0914

Journal of Biological Chemistry (2015)

Basarab GS, Doig P, Galullo V, Kern G, Kimzey A, Kutschke A, Newman J, Morningstar M, Mueller J, Otterson L, Vishwanathan K, Zhou F, Gowravaram M

Discovery of Novel DNA Gyrase Inhibiting Spiropyrimidinetriones – Benzisoxazole Fusion with N-Linked Oxazolidinone Substituents Leading to a Clinical Candidate (ETX0914)

Journal of Medicinal Chemistry (2015)

Perros M

A sustainable model for antibiotics

Science (2015)

Nayar A, Dougherty T, Ferguson K, Granger B, McWilliams L, Stacey C, Narita S, Tokuda H, Miller A, Brown D, McLeod S

Novel antibacterial targets and compounds revealed by a high throughput cell wall reporter assay

ASM Journal of Bacteriology (2015)