Publications

Basarab GS, Kern G, McNulty J, Mueller JP, Lawrence K, Vishwanathan K, Alm RA, Barvian K, Doig P, Galullo V, Gardner H, Gowravaram M, Huband M, Kimzey A, Morningstar M, Kutschke A, Lahiri SD, Perros M, Singh R, Schuck V, Tommasi R, Walkup G, and Newman J

Responding to the challenge of untreatable gonorrhea: ETX0914, a first-in-class agent with a distinct mechanism-of-action against bacterial type II topoisomerases

Nature Scientific Reports (2015)

Kern G, Palmer T, Ehmann DE, Shapiro AB, Andrews B, Basarab GS, Doig P, Fan J, Gao N, Mills SD, Mueller J, Sriram S, Thresher J, and Walkup G

Inhibition of Neisseria gonorrhoeae type II topoisomerases by the novel spiropyrimidinetrione AZD0914

Journal of Biological Chemistry (2015)

Basarab GS, Doig P, Galullo V, Kern G, Kimzey A, Kutschke A, Newman J, Morningstar M, Mueller J, Otterson L, Vishwanathan K, Zhou F, and Gowravaram M

Discovery of novel DNA gyrase inhibiting spiropyrimidinetriones – benzisoxazole fusion with N-linked oxazolidinone substituents leading to a clinical candidate (ETX0914)

Journal of Medicinal Chemistry (2015)

Waites KB, Crabb DM, Duffy LB, and Huband MD

In vitro Antibacterial activity of AZD0914 against human mycoplasmas and ureaplasmas

Antimicrobial Agents and Chemotherapy (2015)

Unemo M, Ringlander J, Wiggins C, Fredlund H, Jacobsson S, and Cole M

High in vitro susceptibility to the novel spiropyrimidinetrione ETX0914 (also known as AZD0914) among 873 contemporary clinical Neisseria gonorrhoeae isolates in 21 European countries during 2012-2014

Antimicrobial Agents and Chemotherapy (2015)

Alm RA, Lahiri SD, Kutschke A, Otterson LG, McLaughlin RE, Whiteaker JD, Lewis LA, Su X, Huband MD, Gardner H, and Mueller JP

Characterization of the novel DNA gyrase inhibitor AZD0914: low resistance potential and lack of cross-resistance in Neisseria gonorrhoeae

Antimicrobial Agents and Chemotherapy (2015)

Jacobsson S, Golparian D, Alm RA, Huband M, Mueller J, Skov Jensen J, Ohnishi M, and Unemo M

High in vitro activity of the novel spiropyrimidinetrione AZD0914, a DNA gyrase inhibitor, against multidrug resistant Neisseria gonorrhoeae isolates suggests a new effective option for oral treatment of gonorrhea

Antimicrobial Agents and Chemotherapy (2014)

Kohlhoff SA, Huband MD, and Hammerschlag MR

In vitro activity of AZD0914, a novel DNA gyrase inhibitor, against Chlamydia trachomatis and Chlamydia pneumoniae

Antimicrobial Agents and Chemotherapy (2014)

Huband MD, Bradford PA, Otterson LG, Basarab GS, Kutschke AC, Giacobbe RA, Patey SA, Alm RA, Johnstone MR, Potter ME, Miller PF, and Mueller JP

In vitro antibacterial activity of AZD0914: a new spiropyrimidinetrione DNA gyrase/topoisomerase inhibitor with potent activity against Gram-positive, fastidious Gram-negative, and atypical bacteria

Antimicrobial Agents and Chemotherapy (2015)

Basarab GS, Brassil P, Doig P, Galullo V, Haimes HB, Kern G, Kutschke A, McNulty J, Schuck VJ, Stone G, and Gowravaram M

Novel DNA gyrase inhibiting spiropyrimidinetriones with a benzisoxazole scaffold: SAR and in vivo characterization

Journal of Medicinal Chemistry (2014)