Publications

Our scientific publications in high-quality journals reflect the quality of the innovative research in Entasis’ laboratories.

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Biedenbach DJ, Huband MD, Hackel M, de Jonge BL, Sahm DF, Bradford PA

In vitro Activity of AZD0914, a Novel Bacterial DNA Gyrase/Topoisomerase IV Inhibitor, Against Clinically Relevant Gram-positive and Fastidious Gram-negative Pathogens

Antimicrobial Agents and Chemotherapy (2015)

Basarab GS, Kern G, McNulty J, Mueller JP, Lawrence K, Vishwanathan K, Alm RA, Barvian K, Doig P, Galullo V, Gardner H, Gowravaram M, Huband M, Kimzey A, Morningstar M, Kutschke A, Lahiri SD, Perros M, Singh R, Schuck V, Tommasi R, Walkup G, Newman J

Responding to the challenge of untreatable gonorrhea: ETX0914, a first-in-class agent with a distinct mechanism-of-action against bacterial Type II topoisomerases

Nature Scientific Reports (2015)

Kern G , Palmer T, Ehmann DE, Shapiro AB, Andrews B, Basarab GS, Doig P, Fan J, Gao N, Mills SD, Mueller J, Sriram S, Thresher J, Walkup G

Inhibition of Neisseria gonorrhoeae type II Topoisomerases by the Novel Spiropyrimidinetrione AZD0914

Journal of Biological Chemistry (2015)

Basarab GS, Doig P, Galullo V, Kern G, Kimzey A, Kutschke A, Newman J, Morningstar M, Mueller J, Otterson L, Vishwanathan K, Zhou F, Gowravaram M

Discovery of Novel DNA Gyrase Inhibiting Spiropyrimidinetriones – Benzisoxazole Fusion with N-Linked Oxazolidinone Substituents Leading to a Clinical Candidate (ETX0914)

Journal of Medicinal Chemistry (2015)

Waites KB, Crabb DM, Duffy LB, Huband MD

In Vitro Antibacterial Activity of AZD0914 Against Human Mycoplasmas and Ureaplasmas

Antimicrobial Agents and Chemotherapy (2015)

Alm R, Lahiri S, Kutschke A, Otterson L, McLaughlin R, Whiteaker J, Lewis L, Su X, Huband M, Gardner H, Mueller J

Characterization of the novel DNA gyrase inhibitor AZD0914: Low resistance potential and lack of cross-resistance in Neisseria gonorrhoeae

Antimicrobial Agents and Chemotherapy (2014)

Kohlhoff S, Huband M, Hammerschlag M

In vitro activity of AZD0914, a novel DNA gyrase inhibitor, against Chlamydia trachomatis and Chlamydia pneumoniae

Antimicrobial Agents and Chemotherapy (2014)

Huband M, Bradford P, Otterson L, Basarab G, Kutschke A, Giacobbe R, Patey S, Alm R, Johnstone M, Potter M, Miller P, Mueller J

In Vitro Antibacterial Activity of AZD0914: A New Spiropyrimidinetrione DNA Gyrase/Topoisomerase Inhibitor with Potent Activity against Gram-Positive, Fastidious Gram-Negative, and Atypical Bacteria

Antimicrobial Agents and Chemotherapy (2014)