Publications

Our scientific publications in high-quality journals reflect the quality of the innovative research in Entasis’ laboratories.

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Shapiro AB, Moussa SH, McLeod SM, Durand-Reville T and Miller AA

Durlobactam, a new diazabicyclooctane β-lactamase inhibitor for the treatment of Acinetobacter infections in combination with sulbactam

Frontiers in Microbiology (2021)

Jacobsson S, Golparian D, Oxelbark J, Alirol FF, Gustafsson TN, Brown D, Louie A, Drusano G and Unemo M

Pharmacodynamic evaluation of dosing, bacterial kill, and resistance suppression for zoliflodacin against Neisseria gonorrhoeae in a dynamic hollow fiber infection model

Frontiers in Pharmacology (2021)

O'Donnell J, Maloney K, Steidler M, Morrison R and Isaacs R

A randomized, double-blind, placebo- and positive-controlled crossover study of the effects of durlobactam on cardiac repolarization in healthy subjects

Clinical and Translational Science (2021)

Papp-Wallace KM, Shapiro AB, Becka SA, Zeiser ET, LiPuma JJ, Lane DJ, Panchal RG, Mueller JP, O'Donnell JP, and Miller AA

In vitro activity and in vivo efficacy of sulbactam-durlobactam against pathogenic Burkholderia species

Antimicrobial Agents and Chemotherapy (2021)

Le W, Su X, Lou X, Li X, Gong X, Wang B, Genco CA, Mueller JP and Rice PA

Susceptibility trends of zoliflodacin against multidrug-resistant Neisseria gonorrhoeae clinical isolates in Nanjing, China (2014-2018)

Antimicrobial Agents and Chemotherapy (2021)

Furuya T, Shapiro AB, Comita-Prevoir J, Kuenstner EJ, Zhang J, Ribe SD, Chen A, Hines D, Moussa SH, Carter NM, Sylvester MA, Romero JAC, Vega CV, Sacco MD, Chen Y, O’Donnell JP, Durand-Reville TF, Miller AA and Tommasi RA

N-Hydroxyformamide LpxC inhibitors, their in vivo efficacy in a mouse Escherichia coli infection model, and their safety in a rat hemodynamic assay

Bioorganic and Medicinal Chemistry (2020)

Theuretzbacher U, Barbee L, Connolly K, Drusano G, Fernandes P, Hook E, Jerse A, O'Donnell J, Unemo M, Van Bambeke F, VanScoy B, Warn P, Werth BJ, Franceschi F, and Alirol E

Pharmacokinetic/pharmacodynamic considerations for new and current therapeutic drugs for uncomplicated gonorrhoea – challenges and opportunities

Clinical Microbiology and Infection (2020)

Durand-Réville TF, Comita-Prevoir J, Zhang J, Wu X, May-Dracka T, Romero T, Wu F, Chen A, Shapiro AB, Carter N, McLeod S, Giacobbe R, Verheijen J, Lahiri S, Sacco M, Chen Y, O’Donnell J, Miller AA, Mueller JP, and Tommasi R

Discovery of an orally available diazabicyclooctane inhibitor (ETX0282) of class A, C and D serine β-lactamases

Journal of Medicinal Chemistry (2020)