Leadership

The Entasis Leadership Team

The team at Entasis combines deep scientific expertise with senior leadership experience in the global pharmaceutical industry. We focus on research excellence in the delivery of the next generation of antibacterials to patients, and on cultivating a great place to work. We are seeking to engage with external partners to fully realize the potential and value of our solid pipeline of candidate medicines.

Manos Perros, PhD

President and Chief Executive Officer

Manos Perros, Ph.D., has served as our chief executive officer, co-founder and director since May 2015. Prior to this, Dr. Perros worked for AstraZeneca AB as vice president and head of its infection research and early development organization from 2010 to 2015 and as site head for its research center in Waltham, Massachusetts from 2012 to 2015. Prior to joining AstraZeneca, Dr. Perros served as director of the Novartis Institute for Tropical Diseases in Singapore, and prior to that, as vice-president and chief scientific officer, antivirals, at Pfizer, Inc. A chemist by training, Dr. Perros conducted his Ph.D. work in Belgium, France and Germany, and was an associate in the Biophysics department at Yale from 1993 to 1995. Dr. Perros received the PhRMA Discoverer’s Award in 2010.

Michael Gutch, PhD

Chief Business Officer / Chief Financial Officer

Michael Gutch, Ph.D., has served as our chief business officer and chief financial officer since April 2017. From January 2014 to March 2017, he served as executive director of corporate development and head of equities at AstraZeneca. Dr. Gutch served as managing director, MedImmune Ventures, the corporate venture capital arm of AstraZeneca, from September 2011 to December 2013. Prior to that, Dr. Gutch served as investment director of HIG BioVentures at the investment firm HIG Capital and as a principal of Lilly Ventures, the corporate venture arm of Eli Lilly & Company. He currently serves on the boards of directors of Albireo Pharma, Inc. Dr. Gutch received his MBA in Finance from Indiana University and a Ph.D. in Molecular Pathology from SUNY Stony Brook. He earned his B.S. degrees in Biology and Chemistry from Alfred University.

David Altarac MD, MPA

Chief Medical Officer

David Altarac MD, MPA joins Entasis as our new Chief Medical Officer.  Prior to this, David was a Senior Vice President and Head of Global Regulatory Affairs, Global Drug Safety and R&D Quality and Compliance at Shire Inc. Prior to joining Shire, David spent two years as VP, Regulatory Affairs at NeoStem, a biopharmaceutical company developing novel, cell-based, individualized therapeutics. Before joining NeoStem, David spent over 13 years at Merck & Company where he served on multiple senior leadership teams. David holds an M.D. degree from New York Medical College, a Master of Public Administration (M.P.A.) degree from New York University, and a B.A. in Chemistry from the State University of New York at Binghamton, New York. David completed his Internal Medicine residency and Infectious Diseases fellowship at Beth Israel Medical Center in New York. David has been the principle and co-investigator on TB, HIV and STD grants funded by the CDC, NIH, and New York State Department of Health. David has held multiple academic, hospital and post graduate teaching appointments during his career and has authored/coauthored numerous scientific publications.

John Mueller, PhD

Chief Development Officer

John Mueller, Ph.D., has served as our chief development officer since May 2015. Prior to this, Dr. Mueller served as senior project director at AstraZeneca AB from June 2011 to May 2015, where he led a global multidisciplinary team to advance zoliflodacin into a Phase 2 clinical trial. Prior to that, Dr. Mueller worked at Pfizer, Inc. and Alexion Pharmaceuticals, Inc. Dr. Mueller received his Ph.D. in Microbiology and Immunology from the Albany Medical College, and subsequently conducted post-doctoral studies at the Tufts Medical School as a National Institutes of Health fellow where he completed his bacterial genetics research training.

Ruben Tommasi, PhD

Chief Scientific Officer

Ruben Tommasi, Ph.D., has served as our chief scientific officer since May 2015. Prior to this, Dr. Tommasi served as executive director of chemistry of the infection innovative medicines unit at AstraZeneca AB from May 2011 to May 2015. Before that, he led the infection chemistry unit at Novartis Institutes for Biomedical Research from December 2006 to April 2011. Prior to that, Dr. Tommasi worked at Novartis International AG. Dr. Tommasi received both his Ph.D. in Organic Chemistry and his Bachelors of Science from the State University of New York, Albany.

Betzy Keiley

General Counsel

Elizabeth Keiley has served as our general counsel since April 2019. Prior to this, Ms. Keiley served in a variety of positions at Oxford Immunotec Global PLC, a publicly traded global diagnostics company, including most recently serving as Senior Vice President and General Counsel. Prior to joining Oxford Immunotec in 2012, Ms. Keiley was assistant general counsel of Zimmer, Inc., a subsidiary of Zimmer Holdings, Inc., an orthopedic device manufacturer. Prior to working at Zimmer, Ms. Keiley was a trial lawyer and partner with Wildman, Harrold, Allen & Dixon in Chicago, Illinois. Ms. Keiley received her B.S. and B.A. degrees in Psychology and Philosophy, respectively, from Boston College and her J.D. from Loyola University School of Law.

Colleen Tucker

Head of Human Resources

Colleen joins Entasis with over 20 years of progressive experience in Human Resources leadership.   Most recently, Colleen has worked as a consultant in the biotech industry, providing creative HR solutions for her clients in areas including talent acquisition, employee relations, executive coaching, employee engagement, strategy planning and learning & development. Prior to consulting, Colleen spent 11 years at Momenta Pharmaceuticals, where she served as Senior Director of Human Resources.  Colleen holds a Bachelor of Arts in Psychology from Providence College and a Master of Science in Human Resources Management from Lesley University. 

Matthew Ronsheim, PhD

Chief Pharmaceutical Sciences & Manufacturing Officer

Prior to joining Entasis, Dr. Ronsheim served as Executive Director and Head of Chemistry Manufacturing and Controls at Enanta Pharmaceuticals.  Previously, Dr. Ronsheim was Director Project Leadership and Global Pharmaceutical Commercialization at Merck/Cubist.  Before joining Merck, Dr. Ronsheim held several leadership roles including Director and Head of Chemical Development, as well as overall program leadership roles in Pharmaceutical Development at Forest Laboratories.  Dr. Ronsheim holds a B.S. in Chemistry from Southern Connecticut State University and a Ph.D. in Synthetic Organic Chemistry from the University of New Hampshire.