Publications

Our scientific publications in high-quality journals reflect the quality of the innovative research in Entasis’ laboratories.

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Lancaster JW, Mahoney MV, Mandal S, Lawrence KR

Update on Treatment Options for Gonococcal Infections

Pharmacotherapy (2015)

Biedenbach DJ, Huband MD, Hackel M, de Jonge BL, Sahm DF, Bradford PA

In vitro Activity of AZD0914, a Novel Bacterial DNA Gyrase/Topoisomerase IV Inhibitor, Against Clinically Relevant Gram-positive and Fastidious Gram-negative Pathogens

Antimicrobial Agents and Chemotherapy (2015)

Basarab GS, Kern G, McNulty J, Mueller JP, Lawrence K, Vishwanathan K, Alm RA, Barvian K, Doig P, Galullo V, Gardner H, Gowravaram M, Huband M, Kimzey A, Morningstar M, Kutschke A, Lahiri SD, Perros M, Singh R, Schuck V, Tommasi R, Walkup G, Newman J

Responding to the challenge of untreatable gonorrhea: ETX0914, a first-in-class agent with a distinct mechanism-of-action against bacterial Type II topoisomerases

Nature Scientific Reports (2015)

Kern G , Palmer T, Ehmann DE, Shapiro AB, Andrews B, Basarab GS, Doig P, Fan J, Gao N, Mills SD, Mueller J, Sriram S, Thresher J, Walkup G

Inhibition of Neisseria gonorrhoeae type II Topoisomerases by the Novel Spiropyrimidinetrione AZD0914

Journal of Biological Chemistry (2015)

Basarab GS, Doig P, Galullo V, Kern G, Kimzey A, Kutschke A, Newman J, Morningstar M, Mueller J, Otterson L, Vishwanathan K, Zhou F, Gowravaram M

Discovery of Novel DNA Gyrase Inhibiting Spiropyrimidinetriones – Benzisoxazole Fusion with N-Linked Oxazolidinone Substituents Leading to a Clinical Candidate (ETX0914)

Journal of Medicinal Chemistry (2015)

Perros M

A sustainable model for antibiotics

Science (2015)

Nayar A, Dougherty T, Ferguson K, Granger B, McWilliams L, Stacey C, Narita S, Tokuda H, Miller A, Brown D, McLeod S

Novel antibacterial targets and compounds revealed by a high throughput cell wall reporter assay

ASM Journal of Bacteriology (2015)

Penwell W, Giacobbe R, Gu R, Patey S, Shapiro S, Gao N, Thresher J, McLaughlin R, Huband M, De Jonge B, Ehmann D, Miller A

The molecular mechanisms of sulbactam antibacterial activity and resistance determinants in Acinetobacter baumannii

Antimicrobial Agents and Chemotherapy (2015)

Waites KB, Crabb DM, Duffy LB, Huband MD

In Vitro Antibacterial Activity of AZD0914 Against Human Mycoplasmas and Ureaplasmas

Antimicrobial Agents and Chemotherapy (2015)

Tommasi R, Brown DG, Walkup GK, Manchester JI, Miller AA

ESKAPing the Labyrinth of Antibacterial Discovery

Nature Reviews Drug Discovery (2015)