Title: Principal Scientist, API Synthesis

Location: Waltham, MA

About Entasis Therapeutics

Entasis is developing a portfolio of innovative product candidates to treat serious Gram-negative multi-drug resistant infections.  Entasis’ anti-infective discovery platform has produced a pipeline of meaningfully differentiated programs which target serious bacterial infections.

Key Responsibilities: 

  • Drive synthetic aspects of drug discovery projects from early discovery stage to clinical candidate
  • Contribute in a very impactful manner to analog synthesis and new route identification for all portfolio projects
  • Strong presence in the lab with high level of productivity
  • Closely collaborate with CMC team on manufacturing campaigns
  • Demonstrate teamwork and promote an open and innovative culture within a cross discipline environment
  • Work in accordance to local safety requirements and in compliance with all company policies

Minimum Qualifications:

  • PhD in Chemistry with 5-10 years of research experience in a biopharmaceutical setting
  • In-depth knowledge of modern organic chemistry and synthesis techniques and tools with demonstrated impact on several drug discovery campaigns
  • Proven track record of solving complex synthetic challenges
  • Ability to successfully design and implement novel chemistry routes within large cross-functional project teams
  • Strong publication record in peer-reviewed journals and/or evidence of sustained contributions to the industry
  • Team player with a positive and proactive attitude with respect to out-of-box thinking, multitasking and willingness to learn and challenge status quo
  • Excellent writing and verbal communication; strong computer, scientific, and organizational skills
  • Able to operate effectively in a multidisciplinary matrix research environment

Preferred Qualifications:

  • Experience in process chemistry, including GLP/GMP manufacturing
  • Experience working with external CROs, including project planning and prioritization of work, as well as academic/industrial collaborations
  • Experience in successfully leading projects to key milestones

Business Knowledge:

Candidate should also have a good understanding of preclinical drug discovery path from idea to clinical candidate. Understands how the different disciplines contribute to the discovery projects and is fully able to represent their own discipline in a cross-disciplinary environment.

Apply Now